Randomizované studie 2014
A randomized phase III trial comparing induction chemotherapy followed by chemoradiotherapy versus chemoradiotherapy alone as treatment of unresectable head and neck cancer.
Ann Oncol. 2014 Jan;25(1):216-25.
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A prospective randomized trial comparing hypofractionation with conventional fractionation radiotherapy for T1-2 glottic squamous cell carcinomas: Results of a Korean Radiation Oncology Group (KROG-0201) study.
Radiother Oncol. 2014 Jan;110(1):98-103.
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Comparison of efficacy for postoperative chemotherapy and concurrent radiochemotherapy in patients with IIIA-pN2 non-small cell lung cancer: An early closed randomized controlled trial.
Radiother Oncol. 2014 Jan;110(1):120-5.
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An international phase 3 trial in head and neck cancer: quality of life and symptom results: EORTC 24954 on behalf of the EORTC Head and Neck and the EORTC Radiation Oncology Group.
Cancer. 2014 Feb 1;120(3):390-8.
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A randomized trial of bevacizumab for newly diagnosed glioblastoma.
N Engl J Med. 2014 Feb 20;370(8):699-708.
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Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma.
N Engl J Med. 2014 Feb 20;370(8):709-22.
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SPECT Analysis of Cardiac Perfusion Changes After Whole-Breast/Chest Wall Radiation Therapy With or Without Active Breathing Coordinator: Results of a Randomized Phase 3 Trial.
Int J Radiat Oncol Biol Phys. 2014 Mar 15;88(4):778-85.
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Phase 3 trial of domiciliary humidification to mitigate acute mucosal toxicity during radiation therapy for head-and-neck cancer: first report of Trans Tasman Radiation Oncology Group (TROG) 07.03 RadioHUM study.
Int J Radiat Oncol Biol Phys. 2014 Mar 1;88(3):572-9.
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Concomitant cisplatin plus radiotherapy and high-dose-rate brachytherapy versus radiotherapy alone for stage IIIB epidermoid cervical cancer: a randomized controlled trial.
J Clin Oncol. 2014 Feb 20;32(6):542-7.
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Fluorouracil-based adjuvant chemotherapy after preoperative chemoradiotherapy in rectal cancer: long-term results of the EORTC 22921 randomised study.
Lancet Oncol. 2014 Feb;15(2):184-90.
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Single versus multiple fractions of repeat radiation for painful bone metastases: a randomised, controlled, non-inferiority trial.
Lancet Oncol. 2014 Feb;15(2):164-71.
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Risk factors for clinician-reported symptom clusters in patients with advanced head and neck cancer in a phase 3 randomized clinical trial: RTOG 0129.
Cancer. 2014 Mar 15;120(6):848-54.
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The Erlangen Dose Optimization trial for low-dose radiotherapy of benign painful elbow syndrome. Long-term results.
Strahlenther Onkol. 2014 Mar;190(3):293-7.
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The Erlangen Dose Optimization Trial for radiotherapy of benign painful shoulder syndrome. Long-term results.
Strahlenther Onkol. 2014 Apr;190(4):394-8.
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Radiotherapy for benign calcaneodynia : Long-term results of the Erlangen Dose Optimization (EDO) trial.
Strahlenther Onkol. 2014 Jul;190(7):671-675.
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Adjuvant radiotherapy in centrally located hepatocellular carcinomas after hepatectomy with narrow margin (<1 cm): a prospective randomized study.
J Am Coll Surg. 2014 Mar;218(3):381-92.
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Sector resection with or without postoperative radiotherapy for stage I breast cancer: 20-year results of a randomized trial.
J Clin Oncol. 2014 Mar 10;32(8):791-7.
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Brachytherapy boost in loco-regionally advanced nasopharyngeal carcinoma: a prospective randomized trial of the International Atomic Energy Agency.
Radiat Oncol. 2014 Mar 1;9(1):67.
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Omitting radiotherapy in early positron emission tomography-negative stage I/II Hodgkin lymphoma is associated with an increased risk of early relapse: Clinical results of the preplanned interim analysis of the randomized EORTC/LYSA/FIL H10 trial.
J Clin Oncol. 2014 Apr 20;32(12):1188-94.
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Tadalafil for prevention of erectile dysfunction after radiotherapy for prostate cancer: the Radiation Therapy Oncology Group [0831] randomized clinical trial.
JAMA. 2014 Apr 2;311(13):1300-7.
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Risk of late toxicity in men receiving dose-escalated hypofractionated intensity modulated prostate radiation therapy: results from a randomized trial.
Int J Radiat Oncol Biol Phys. 2014 Apr 1;88(5):1074-84.
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4 Gy versus 24 Gy radiotherapy for patients with indolent lymphoma (FORT): a randomised phase 3 non-inferiority trial.
Lancet Oncol. 2014 Apr;15(4):457-63.
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Phase III placebo-controlled double-blind randomized trial of radiotherapy for stage IIB-IVA cervical cancer with or without immunomodulator Z-100: a JGOG study.
Ann Oncol. 2014 May;25(5):1011-.
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Conventional stents versus stents loaded with (125)iodine seeds for the treatment of unresectable oesophageal cancer: a multicentre, randomised phase 3 trial.
Lancet Oncol. 2014 May;15(6):612-9.
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Doxepin rinse versus placebo in the treatment of acute oral mucositis pain in patients receiving head and neck radiotherapy with or without chemotherapy: a phase III, randomized, double-blind trial (NCCTG-N09C6 [Alliance]).
J Clin Oncol. 2014 May 20;32(15):1571-7.
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Final results of local-regional control and late toxicity of RTOG 9003: a randomized trial of altered fractionation radiation for locally advanced head and neck cancer.
Int J Radiat Oncol Biol Phys. 2014 May 1;89(1):13-20.
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Patient reported outcome measures (PROMs) following forward planned field-in field IMRT: Results from the Cambridge Breast IMRT trial.
Radiother Oncol. 2014 May;111(2):270-5.
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Poor prognosis patients with inoperable locally advanced NSCLC and large tumors benefit from palliative chemoradiotherapy: a subset analysis from a randomized clinical phase III trial.
Thorac Oncol. 2014 Jun;9(6):825-33J.
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Effect of radium-223 dichloride on symptomatic skeletal events in patients with castration-resistant prostate cancer and bone metastases: results from a phase 3, double-blind, randomised trial.
Lancet Oncol. 2014 Jun;15(7):738-46.
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Escalated-dose versus control-dose conformal radiotherapy for prostate cancer: long-term results from the MRC RT01 randomised controlled trial.
Lancet Oncol. 2014 Apr;15(-734):464.
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Prospective, randomized, controlled, and open study in primarily inoperable, stage III non-small cell lung cancer (NSCLC) patients given sequential radiochemotherapy with or without epoetin alfa.
Radiother Oncol. 2014 Jul;112(1):23-9.
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Effects of voice rehabilitation after radiation therapy for laryngeal cancer: a randomized controlled study.
Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):964-72.
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Randomized trial of hyperfractionation versus conventional fractionation in T2 squamous cell carcinoma of the vocal cord (RTOG 9512)..
Int J Radiat Oncol Biol Phys. 2014 Aug 1;89(5):958-63 .
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Long-term results of a randomized trial in locally advanced rectal cancer: no benefit from adding a brachytherapy boost.
Int J Radiat Oncol Biol Phys. 2014 Sep 1;90(1):110-8.
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Phase III Randomized Trial of Induction Chemotherapy in Patients With N2 or N3 Locally Advanced Head and Neck Cancer.
J Clin Oncol. 2014 Sep 1;32(25):2735-43.
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Surgery alone versus chemoradiotherapy followed by surgery for stage I and II esophageal cancer: final analysis of randomized controlled phase III trial FFCD 9901.
J Clin Oncol. 2014 Aug 10;32(23):2416-22.
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Impact of brachytherapy on local recurrence rates after sublobar resection: results from ACOSOG Z4032 (Alliance), a phase III randomized trial for high-risk operable non-small-cell lung cancer.
J Clin Oncol. 2014 Aug 10;32(23):2456-62.
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Increased cardio and cerebrovascular mortality in breast cancer patients treated with postmastectomy radiotherapy--25 year follow-up of a randomised trial from the South Sweden Breast Cancer Group.
Eur J Cancer. 2014 Sep;50(13):2201-10.
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Split-course accelerated hyperfractionated irradiation (CHA-CHA) as a sole treatment for advanced head and neck cancer patients-final results of a randomized clinical trial.
Br J Radiol. 2014 Sep;87(1041):20140212.
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Health-related quality of life 14 years after preoperative short-term radiotherapy and total mesorectal excision for rectal cancer: report of a multicenter randomised trial.
Eur J Cancer. 2014 Sep;50(14):2390-8.
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Consequences of anorectal cancer atlas implementation in the cooperative group setting: Radiobiologic analysis of a prospective randomized in silico target delineation study.
Radiother Oncol. 2014 Sep;112(3):418-24.
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Voice quality after treatment of early vocal cord cancer: a randomized trial comparing laser surgery with radiation therapy.
Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):255-60.
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Efficacy of synbiotics to reduce acute radiation proctitis symptoms and improve quality of life: a randomized, double-blind, placebo-controlled pilot trial.
Int J Radiat Oncol Biol Phys. 2014 Oct 1;90(2):289-95.
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No benefit of adjuvant Fluorouracil Leucovorin chemotherapy after neoadjuvant chemoradiotherapy in locally advanced cancer of the rectum (LARC): Long term results of a randomized trial (I-CNR-RT).
Radiother Oncol. 2014 Nov;113(2):223-9.
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Effect of radiotherapy after breast-conserving surgery for ductal carcinoma in situ: 20 years follow-up in the randomized SweDCIS Trial.
J Clin Oncol. 2014 Nov 10;32(32):3613-8.
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Effects of a dietary intervention on gastrointestinal symptoms after prostate cancer radiotherapy: Long-term results from a randomized controlled trial.
Radiother Oncol. 2014 Nov;113(2):240-7.
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Secondary analysis of RTOG 9508, a phase 3 randomized trial of whole-brain radiation therapy versus WBRT plus stereotactic radiosurgery in patients with 1-3 brain metastases; poststratified by the graded prognostic assessment (GPA).
Int J Radiat Oncol Biol Phys. 2014 Nov 1;90(3):526-31.
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Natural oil-based emulsion containing allantoin versus aqueous cream for managing radiation-induced skin reactions in patients with cancer: a phase 3, double-blind, randomized, controlled trial.
Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):756-64.
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Evaluating the effects of aluminum-containing and non-aluminum containing deodorants on axillary skin toxicity during radiation therapy for breast cancer: a 3-armed randomized controlled trial.
Int J Radiat Oncol Biol Phys. 2014 Nov 15;90(4):765-71..
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Short-term androgen suppression and radiotherapy versus intermediate-term androgen suppression and radiotherapy, with or without zoledronic acid, in men with locally advanced prostate cancer (TROG 03.04 RADAR): an open-label, randomised, phase 3 factorial trial.
Lancet Oncol. 2014 Sep;15(10):1076-89.
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Randomized phase III trial of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III to IV head and neck carcinoma: RTOG 0522.
J Clin Oncol. 2014 Sep 20;32(27):2940-50.
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Radiotherapy or surgery of the axilla after a positive sentinel node in breast cancer (EORTC 10981-22023 AMAROS): a randomised, multicentre, open-label, phase 3 non-inferiority trial.
Lancet Oncol. 2014 Nov;15(12):1303-10.
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Efficacy and safety of radium-223 dichloride in patients with castration-resistant prostate cancer and symptomatic bone metastases, with or without previous docetaxel use: a prespecified subgroup analysis from the randomised, double-blind, phase 3 ALSYMPCA trial.
Lancet Oncol. 2014 Nov;15(12):1397-406.
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Randomized phase III trial to test accelerated versus standard fractionation in combination with concurrent cisplatin for head and neck carcinomas in the Radiation Therapy Oncology Group 0129 trial: long-term report of efficacy and toxicity.
J Clin Oncol. 2014 Dec 1;32(34):3858-66.
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