Randomizované studie 2016
5-year results of accelerated partial breast irradiation using sole interstitial multicatheter brachytherapy versus whole-breast irradiation with boost after breast-conserving surgery for low-risk invasive and in-situ carcinoma of the female breast: a randomised, phase 3, non-inferiority trial.
Lancet. 2016 Jan 16;387(10015):229-38.
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Randomized non-inferiority trial of Bicalutamide and Dutasteride versus LHRH agonists for prostate volume reduction prior to I-125 permanent implant brachytherapy for prostate cancer.
Radiother Oncol. 2016 Jan;118(1):141-7.
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Outcome According to Elective Pelvic Radiation Therapy in Patients With High-Risk Localized Prostate Cancer: A Secondary Analysis of the GETUG 12 Phase 3 Randomized Trial.
Int J Radiat Oncol Biol Phys. 2016 Jan 1;94(1):85-92.
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Role of Surgical Versus Clinical Staging in Chemoradiated FIGO Stage IIB-IVA Cervical Cancer Patients-Acute Toxicity and Treatment Quality of the Uterus-11 Multicenter Phase III Intergroup Trial of the German Radiation Oncology Group and the Gynecologic Cancer Group.
Int J Radiat Oncol Biol Phys. 2016 Feb 1;94(2):243-53.
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Differences in health related quality of life in the randomised ARTSCAN study; accelerated vs. conventional radiotherapy for head and neck cancer. A five year follow up.
Radiother Oncol. 2016 Feb;118(2):335-41.
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Effectiveness of an (18)F-FDG-PET based strategy to optimize the diagnostic trajectory of suspected recurrent laryngeal carcinoma after radiotherapy: The RELAPS multicenter randomized trial.
Radiother Oncol. 2016 Feb;118(2):251-6.
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Wide versus narrow excision margins for high-risk, primary cutaneous melanomas: long-term follow-up of survival in a randomised trial.
Lancet Oncol. 2016 Feb;17(2):184-92.
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Pathologic Response, When Increased by Longer Interval, Is a Marker but Not the Cause of Good Prognosis in Rectal Cancer: 17-year Follow-up of the Lyon R90-01 Randomized Trial.
Int J Radiat Oncol Biol Phys. 2016 Mar 1;94(3):544-53.
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PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer.
N Engl J Med. 2016 Apr 14;374(15):1444-54.
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Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma.
N Engl J Med. 2016 Apr 7;374(14):1344-55.
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Prospective randomized controlled trial to compare 3-dimensional conformal radiotherapy to intensity-modulated radiotherapy in head and neck squamous cell carcinoma: Long-term results.
Head Neck. 2016 Apr;38 Suppl 1:E1481-7.
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A randomized clinical trial of neoadjuvant chemotherapy versus neoadjuvant chemoradiotherapy for cancer of the oesophagus or gastro-oesophageal junction.
Ann Oncol. 2016 Apr;27(4):660-7.
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Hypofractionated versus conventionally fractionated radiotherapy for patients with prostate cancer (HYPRO): late toxicity results from a randomised, non-inferiority, phase 3 trial.
Lancet Oncol. 2016 Apr;17(4):464-74.
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Quality-of-life after radiotherapy for advanced laryngeal cancer: Results of a phase III trial of the Dutch Head and Neck Society.
Radiother Oncol. 2016 May;119(2):213-20.
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Short Androgen Suppression and Radiation Dose Escalation for Intermediate- and High-Risk Localized Prostate Cancer: Results of EORTC Trial 22991.
J Clin Oncol. 2016 May 20;34(15):1748-56.
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Effect of Chemoradiotherapy vs Chemotherapy on Survival in Patients With Locally Advanced Pancreatic Cancer Controlled After 4 Months of Gemcitabine With or Without Erlotinib: The LAP07 Randomized Clinical Trial.
JAMA. 2016 May 3;315(17):1844-53.
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Long-course oxaliplatin-based preoperative chemoradiation versus 5 × 5 Gy and consolidation chemotherapy for cT4 or fixed cT3 rectal cancer: results of a randomized phase III study.
Ann Oncol. 2016 May;27(5):834-42.
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Prospective Randomized Trial of Prone Accelerated Intensity Modulated Breast Radiation Therapy With a Daily Versus Weekly Boost to the Tumor Bed.
Int J Radiat Oncol Biol Phys. 2016 Jun 1;95(2):571-8.
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Salvage radiotherapy with or without short-term hormone therapy for rising prostate-specific antigen concentration after radical prostatectomy (GETUG-AFU 16): a randomised, multicentre, open-label phase 3 trial.
Lancet Oncol. 2016 Jun;17(6):747-56.
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N08C9 (Alliance): A Phase 3 Randomized Study of Sulfasalazine Versus Placebo in the Prevention of Acute Diarrhea in Patients Receiving Pelvic Radiation Therapy.
Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1168-74.
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Acute skin toxicity associated with a 1-week schedule of whole breast radiotherapy compared with a standard 3-week regimen delivered in the UK FAST-Forward Trial.
Radiother Oncol. 2016 Jul;120(1):114-8.
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Impact of Sequencing Radiation Therapy and Chemotherapy on Long-Term Local Toxicity for Early Breast Cancer: Results of a Randomized Study at 15-Year Follow-Up.
Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1201-9.
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Effect of Radiosurgery Alone vs Radiosurgery With Whole Brain Radiation Therapy on Cognitive Function in Patients With 1 to 3 Brain Metastases: A Randomized Clinical Trial.
JAMA. 2016 Jul 26;316(4):401-9.
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GEC-ESTRO multicenter phase 3-trial: Accelerated partial breast irradiation with interstitial multicatheter brachytherapy versus external beam whole breast irradiation: Early toxicity and patient compliance.
Radiother Oncol. 2016 Jul;120(1):119-23.
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The 2-Year Cosmetic Outcome of a Randomized Trial Comparing Prone and Supine Whole-Breast Irradiation in Large-Breasted Women.
Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1210-7.
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Randomized Phase III Noninferiority Study Comparing Two Radiotherapy Fractionation Schedules in Patients With Low-Risk Prostate Cancer.
J Clin Oncol. 2016 Jul 10;34(20):2325-32.
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Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial.
Cancer. 2016 Jul 1;122(13):2004-11.
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Conventional versus hypofractionated high-dose intensity-modulated radiotherapy for prostate cancer: 5-year outcomes of the randomised, non-inferiority, phase 3 CHHiP trial.
Lancet Oncol. 2016 Aug;17(8):1047-60.
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Toxicity and quality of life after adjuvant chemoradiotherapy versus radiotherapy alone for women with high-risk endometrial cancer (PORTEC-3): an open-label, multicentre, randomised, phase 3 trial.
Lancet Oncol. 2016 Aug;17(8):1114-26.
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Cosmesis and Breast-Related Quality of Life Outcomes After Intraoperative Radiation Therapy for Early Breast Cancer: A Substudy of the TARGIT-A Trial.
Int J Radiat Oncol Biol Phys. 2016 Sep 1;96(1):55-64.
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Long-term update of the 24954 EORTC phase III trial on larynx preservation.
Eur J Cancer. 2016 Sep;65:109-12.
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Longitudinal analysis of patient-reported outcomes and cosmesis in a randomized trial of conventionally fractionated versus hypofractionated whole-breast irradiation.
Cancer. 2016 Sep 15;122(18):2886-94.
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Cetuximab and Radiotherapy in Laryngeal Preservation for Cancers of the Larynx and Hypopharynx: A Secondary Analysis of a Randomized Clinical Trial.
AMA Otolaryngol Head Neck Surg. 2016 Sep 1;142(9):842-9.
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Modified FOLFOX6 With or Without Radiation Versus Fluorouracil and Leucovorin With Radiation in Neoadjuvant Treatment of Locally Advanced Rectal Cancer: Initial Results of the Chinese FOWARC Multicenter, Open-Label, Randomized Three-Arm Phase III Trial.
J Clin Oncol. 2016 Sep 20;34(27):3300-7.
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Dexamethasone and supportive care with or without whole brain radiotherapy in treating patients with non-small cell lung cancer with brain metastases unsuitable for resection or stereotactic radiotherapy (QUARTZ): results from a phase 3, non-inferiority, randomised trial.
Lancet. 2016 Oct 22;388(10055):2004-2014.
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SPACE - A randomized study of SBRT vs conventional fractionated radiotherapy in medically inoperable stage I NSCLC.
Radiother Oncol. 2016 Oct;121(1):1-8.
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Timing of Radiation Therapy and Chemotherapy After Breast-Conserving Surgery for Node-Positive Breast Cancer: Long-Term Results From International Breast Cancer Study Group Trials VI and VII.
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):273-9.
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10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer.
N Engl J Med. 2016 Oct 13;375(15):1415-1424.
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Prognostic Value of p16 Status on the Development of a Complete Response in Involved Oropharynx Cancer Neck Nodes After Cisplatin-Based Chemoradiation: A Secondary Analysis of NRG Oncology RTOG 0129.
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):362-71.
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Late Radiation and Cardiovascular Adverse Effects After Androgen Deprivation and High-Dose Radiation Therapy in Prostate Cancer: Results From the DART 01/05 Randomized Phase 3 Trial.
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):341-8.
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Macroscopic Hematuria After Conventional or Hypofractionated Radiation Therapy: Results From a Prospective Phase 3 Study.
Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2):304-12.
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Induction chemotherapy plus concurrent chemoradiotherapy versus concurrent chemoradiotherapy alone in locoregionally advanced nasopharyngeal carcinoma: a phase 3, multicentre, randomised controlled trial.
Lancet Oncol. 2016 Nov;17(11):1509-1520.
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Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Lancet Oncol. 2016 Nov;17(11):1521-1532.
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Stereotactic radiotherapy of the tumor bed compared to whole brain radiotherapy after surgery of single brain metastasis: Results from a randomized trial.
Radiother Oncol. 2016 Nov;121(2):217-224.
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Temozolomide chemotherapy versus radiotherapy in high-risk low-grade glioma (EORTC 22033-26033): a randomised, open-label, phase 3 intergroup study.
Lancet Oncol. 2016 Nov;17(11):1521-1532.
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Is There a Role for Pelvic Irradiation in Localized Prostate Adenocarcinoma? Update of the Long-Term Survival Results of the GETUG-01 Randomized Study.
Int J Radiat Oncol Biol Phys. 2016 Nov 15;96(4):759-769.
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Prolongation of overall treatment time as a cause of treatment failure in early breast cancer: An analysis of the UK START (Standardisation of Breast Radiotherapy) trials of radiotherapy fractionation.
Radiother Oncol. 2016 Dec;121(3):420-423.
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Does the addition of oxaliplatin to preoperative chemoradiation benefit cT4 or fixed cT3 rectal cancer treatment? A subgroup analysis from a prospective study.
Eur J Surg Oncol. 2016 Dec;42(12):1859-1865.
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Ten years results of the Canadian breast intensity modulated radiation therapy (IMRT) randomized controlled trial.
Radiother Oncol. 2016 Dec;121(3):414-419.
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