Quality of Life Implications of Dose-Escalated External Beam Radiation for Localized Prostate Cancer: Results of a Prospective Randomized Phase 3 Clinical Trial, NRG/RTOG 0126.
Int J Radiat Oncol Biol Phys. 2022 Jan 1;112(1):83-92.
Více informací ZDE
Bone Marrow-sparing Intensity Modulated Radiation Therapy With Concurrent Cisplatin For Stage IB-IVA Cervical Cancer: An International Multicenter Phase II Clinical Trial (INTERTECC-2).
Int J Radiat Oncol Biol Phys. 2017 Mar 1;97(3):536-545.
Více informací ZDE
Results from a prospective, randomised study on (accelerated) preoperative versus (conventional) postoperative radiotherapy in treatment of patients with resectable squamous cell carcinoma of the oral cavity - The ARTSCAN 2 study.
Radiother Oncol. 2022 Jan;166:26-32.
Více informací ZDE
Postoperative radiotherapy versus no postoperative radiotherapy in patients with completely resected non-small-cell lung cancer and proven mediastinal N2 involvement (Lung ART): an open-label, randomised, phase 3 trial.
Lancet Oncol. 2022 Jan;23(1):104-114.
Více informací ZDE
Abiraterone acetate and prednisolone with or without enzalutamide for high-risk non-metastatic prostate cancer: a meta-analysis of primary results from two randomised controlled phase 3 trials of the STAMPEDE platform protocol.
Lancet. 2022 Jan 29;399(10323):447-460.
Více informací ZDE
Radiation Therapy Techniques and Treatment-Related Toxicity in the PORTEC-3 Trial: Comparison of 3-Dimensional Conformal Radiation Therapy Versus Intensity-Modulated Radiation Therapy.
Int J Radiat Oncol Biol Phys. 2022 Feb 1;112(2):390-399.
Více informací ZDE
Parotid Gland Stem Cell Sparing Radiation Therapy for Patients With Head and Neck Cancer: A Double-Blind Randomized Controlled Trial.
Int J Radiat Oncol Biol Phys. 2022 Feb 1;112(2):306-316.
Více informací ZDE
Adding Short-Term Androgen Deprivation Therapy to Radiation Therapy in Men With Localized Prostate Cancer: Long-Term Update of the NRG/RTOG 9408 Randomized Clinical Trial.
Int J Radiat Oncol Biol Phys. 2022 Feb 1;112(2):294-303.
Více informací ZDE
Trastuzumab with trimodality treatment for oesophageal adenocarcinoma with HER2 overexpression (NRG Oncology/RTOG 1010): a multicentre, randomised, phase 3 trial.
Lancet Oncol. 2022 Feb;23(2):259-269.
Více informací ZDE
Sugemalimab versus placebo, in combination with platinum-based chemotherapy, as first-line treatment of metastatic non-small-cell lung cancer (GEMSTONE-302): interim and final analyses of a double-blind, randomised, phase 3 clinical trial.
Lancet Oncol. 2022 Feb;23(2):220-233.
Více informací ZDE
Randomized Phase 3, Double-Blind, Placebo-Controlled Study of Prophylactic Gabapentin for the Reduction of Oral Mucositis Pain During the Treatment of Oropharyngeal Squamous Cell Carcinoma.
Int J Radiat Oncol Biol Phys. 2022 Mar 15;112(4):926-937.
Více informací ZDE
Patient-Reported Outcomes in the Acute Phase of the Randomized Hypofractionated Irradiation for Prostate Cancer (HYPRO) Trial.
Int J Radiat Oncol Biol Phys. 2022 Mar 15;112(4):870-879.
Více informací ZDE
Association of Short-Term Patient-Reported Outcomes With Long-Term Oncologic Outcomes in Localized Prostate Cancer Patients Treated With Radiation Therapy and Androgen Deprivation Therapy in a Randomized Controlled Trial.
Int J Radiat Oncol Biol Phys. 2022 Mar 15;112(4):880-889.
Více informací ZDE
Impact of Dose-Escalated Chemoradiation on Quality of Life in Patients With Locally Advanced Rectal Cancer: 2-Year Follow-Up of the Randomized RECTAL-BOOST Trial.
Int J Radiat Oncol Biol Phys. 2022 Mar 1;112(3):694-703.
Více informací ZDE
Thyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer.
N Engl J Med. 2022 Mar 10;386(10):923-932.
Více informací ZDE
Randomized Trial of Radiotherapy Versus Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Long-Term Results of the ORATOR Trial.
J Clin Oncol. 2022 Mar 10;40(8):866-875.
Více informací ZDE
Early Local Therapy for the Primary Site in De Novo Stage IV Breast Cancer: Results of a Randomized Clinical Trial (EA2108)
J Clin Oncol. 2022 Mar 20;40(9):978-987.
Více informací ZDE
Efficacy and Safety of Autologous Dendritic Cell-Based Immunotherapy, Docetaxel, and Prednisone vs Placebo in Patients With Metastatic Castration-Resistant Prostate Cancer: The VIABLE Phase 3 Randomized Clinical Trial.
JAMA Oncol. 2022 Apr 1;8(4):546-552.
Více informací ZDE
Palliative Radiation for Advanced Central Lung Tumors With Intentional Avoidance of the Esophagus (PROACTIVE): A Phase 3 Randomized Clinical Trial.
JAMA Oncol. 2022 Apr 1;8(4):1-7.
Více informací ZDE
Five-Year Survival Outcomes From the PACIFIC Trial: Durvalumab After Chemoradiotherapy in Stage III Non-Small-Cell Lung Cancer.
J Clin Oncol. 2022 Apr 20;40(12):1301-1311.
Více informací ZDE
Neoadjuvant Chemoradiotherapy Versus Upfront Surgery for Resectable and Borderline Resectable Pancreatic Cancer: Long-Term Results of the Dutch Randomized PREOPANC Trial.
J Clin Oncol. 2022 Apr 10;40(11):1220-1230.
Více informací ZDE
Elective upper-neck versus whole-neck irradiation of the uninvolved neck in patients with nasopharyngeal carcinoma: an open-label, non-inferiority, multicentre, randomised phase 3 trial.
Lancet Oncol. 2022 Apr;23(4):479-490.
Více informací ZDE
Observation versus screening spinal MRI and pre-emptive treatment for spinal cord compression in patients with castration-resistant prostate cancer and spinal metastases in the UK (PROMPTS): an open-label, randomised, controlled, phase 3 trial.
Lancet Oncol. 2022 Apr;23(4):501-513.
Více informací ZDE
High-dose radiotherapy and risk-adapted androgen deprivation in localised prostate cancer (DART 01/05): 10-year results of a phase 3 randomised, controlled trial.
Lancet Oncol. 2022 May;23(5):671-681.
Více informací ZDE
Multicenter, Randomized, Phase III Trial of Short-Term Radiotherapy Plus Chemotherapy Versus Long-Term Chemoradiotherapy in Locally Advanced Rectal Cancer (STELLAR).
J Clin Oncol. 2022 May 20;40(15):1681-1692.
Více informací ZDE
Effect of Induction Chemotherapy With Paclitaxel, Cisplatin, and Capecitabine vs Cisplatin and Fluorouracil on Failure-Free Survival for Patients With Stage IVA to IVB Nasopharyngeal Carcinoma: A Multicenter Phase 3 Randomized Clinical Trial.
JAMA Oncol. 2022 May 1;8(5):706-714.
Více informací ZDE
Diffusion-Weighted Magnetic Resonance Imaging-Guided Dose Painting in Patients With Locoregionally Advanced Nasopharyngeal Carcinoma Treated With Induction Chemotherapy Plus Concurrent Chemoradiotherapy: A Randomized, Controlled Clinical Trial.
Int J Radiat Oncol Biol Phys. 2022 May 1;113(1):101-113.
Více informací ZDE
Postmastectomy radiotherapy in high-risk breast cancer patients given adjuvant systemic therapy. A 30-year long-term report from the Danish breast cancer cooperative group DBCG 82bc trial.
Radiother Oncol. 2022 May;170:4-13.
Více informací ZDE
The addition of androgen deprivation therapy and pelvic lymph node treatment to prostate bed salvage radiotherapy (NRG Oncology/RTOG 0534 SPPORT): an international, multicentre, randomised phase 3 trial.
Lancet. 2022 May 14;399(10338):1886-1901.
Více informací ZDE
Prophylactic Use of Compression Sleeves Reduces the Incidence of Arm Swelling in Women at High Risk of Breast Cancer-Related Lymphedema: A Randomized Controlled Trial.
J Clin Oncol. 2022 Jun 20;40(18):2004-2012.
Více informací ZDE
Weekly Cisplatin Plus Radiation for Postoperative Head and Neck Cancer (JCOG1008): A Multicenter, Noninferiority, Phase II/III Randomized Controlled Trial.
J Clin Oncol. 2022 Jun 20;40(18):1980-1990.
Více informací ZDE
Assessment of Toxic Effects and Survival in Treatment Deescalation With Radiotherapy vs Transoral Surgery for HPV-Associated Oropharyngeal Squamous Cell Carcinoma: The ORATOR2 Phase 2 Randomized Clinical Trial.
JAMA Oncol. 2022 Jun 1;8(6):1-7.
Více informací ZDE
Quality of life and late toxicity after short-course radiotherapy followed by chemotherapy or chemoradiotherapy for locally advanced rectal cancer - The RAPIDO trial.
Radiother Oncol. 2022 Jun;171:69-76.
Více informací ZDE
Effect of Supine vs Prone Breast Radiotherapy on Acute Toxic Effects of the Skin Among Women With Large Breast Size: A Randomized Clinical Trial.
JAMA Oncol. 2022 Jul 1;8(7):994-1000.
Více informací ZDE
Treatment planning comparison in the PROTECT-trial randomising proton versus photon beam therapy in oesophageal cancer: Results from eight European centres.
Radiother Oncol. 2022 Jul;172:32-41.
Více informací ZDE
The association of internal mammary and medial supraclavicular lymph node radiation technique with clinical outcomes: Results from the EORTC 22922/10925 randomised trial.
Radiother Oncol. 2022 Jul;172:99-110.
Více informací ZDE
Effect of Radiotherapy Alone vs Radiotherapy With Concurrent Chemoradiotherapy on Survival Without Disease Relapse in Patients With Low-risk Nasopharyngeal Carcinoma: A Randomized Clinical Trial.
JAMA. 2022 Aug 23;328(8):728-736.
Více informací ZDE
Radiation doses and fractionation schedules in non-low-risk ductal carcinoma in situ in the breast (BIG 3-07/TROG 07.01): a randomised, factorial, multicentre, open-label, phase 3 study.
Lancet. 2022 Aug 6;400(10350):431-440.
Více informací ZDE
Radiation Therapy Dose Escalation in Unresectable Ewing Sarcoma: Final Results of a Phase 3 Randomized Controlled Trial.
Int J Radiat Oncol Biol Phys. 2022 Aug 1;113(5):996-1002.
Více informací ZDE
Joint Final Report of EORTC 26951 and RTOG 9402: Phase III Trials With Procarbazine, Lomustine, and Vincristine Chemotherapy for Anaplastic Oligodendroglial Tumors.
J Clin Oncol. 2022 Aug 10;40(23):2539-2545.
Více informací ZDE
Final Overall Survival Analysis of Gemcitabine and Cisplatin Induction Chemotherapy in Nasopharyngeal Carcinoma: A Multicenter, Randomized Phase III Trial.
J Clin Oncol. 2022 Aug 1;40(22):2420-2425.
Více informací ZDE
Acute Toxicity of Ultrahypofractionation Compared With Moderate Hypofractionation in Prostate Cancer Treatment: A Randomized Trial.
Int J Radiat Oncol Biol Phys. 2022 Aug 1;113(5):1036-1043.
Více informací ZDE
Randomized Trial of Conventional Versus Conventional Plus Fluciclovine (18F) Positron Emission Tomography/Computed Tomography-Guided Postprostatectomy Radiation Therapy for Prostate Cancer: Volumetric and Patient-Reported Analyses of Toxic Effects.
Int J Radiat Oncol Biol Phys. 2022 Aug 1;113(5):1003-1014.
Více informací ZDE
Chemoradiotherapy in Muscle-invasive Bladder Cancer: 10-yr Follow-up of the Phase 3 Randomised Controlled BC2001 Trial.
Eur Urol. 2022 Sep;82(3):273-279.
Více informací ZDE
Intensity-Modulated Radiation Therapy Reduces Patient-Reported Chronic Toxicity Compared With Conventional Pelvic Radiation Therapy: Updated Results of a Phase III Trial.
J Clin Oncol. 2022 Sep 20;40(27):3115-3119.
Více informací ZDE
Mature Local Control and Reirradiation Rates Comparing Spine Stereotactic Body Radiation Therapy With Conventional Palliative External Beam Radiation Therapy.
Int J Radiat Oncol Biol Phys. 2022 Oct 1;114(2):293-300.
Více informací ZDE
Effectiveness of Intensive Versus Minimalist Follow-Up Regimen on Survival in Patients With Endometrial Cancer (TOTEM Study): A Randomized, Pragmatic, Parallel Group, Multicenter Trial.
J Clin Oncol. 2022 Nov 20;40(33):3817-3827.
Více informací ZDE
Stereotactic Radiation for the Comprehensive Treatment of Oligometastases (SABR-COMET): Extended Long-Term Outcomes.
Int J Radiat Oncol Biol Phys. 2022 Nov 15;114(4):611-616.
Více informací ZDE
Phase III trial of chemoradiotherapy with temozolomide plus nivolumab or placebo for newly diagnosed glioblastoma with methylated MGMT promoter.
Neuro Oncol. 2022 Nov 2;24(11):1935-1949.
Více informací ZDE
Final Safety and Health-Related Quality of LIfe Results of the Phase 2/3 Act.In.Sarc Study With Preoperative NBTXR3 Plus Radiation Therapy Versus Radiation Therapy in Locally Advanced Soft-Tissue Sarcoma.
Int J Radiat Oncol Biol Phys. 2022 Nov 1;114(3):422-432.
Více informací ZDE
OPTimizing Irradiation through Molecular Assessment of Lymph node (OPTIMAL): a randomized clinical trial.
Radiother Oncol. 2022 Nov;176:76-82.
Více informací ZDE
Partial Breast Irradiation Versus Whole Breast Irradiation for Early Breast Cancer Patients in a Randomized Phase III Trial: The Danish Breast Cancer Group Partial Breast Irradiation Trial.
J Clin Oncol. 2022 Dec 20;40(36):4189-4197.
Více informací ZDE
Late toxicity within a Phase III clinical trial of IG-IMRT in cervix cancer (PARCER): Reanalysis with time weighted adverse event reporting (MOSES).
Radiother Oncol. 2022 Dec;177:16-20.
Více informací ZDE
